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Md. Asad Khan
Md. Asad Khan
Jamia Millia,
Islamia, New Delhi
India
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Research Article
4-Aminobiphenyl and Nitric Oxide Synergistically Modified Human DNA: It’s Implication in Bladder Cancer
Author(s): Md. Asad Khan, Kiran Dixit, Moinuddin and Khursheed AlamMd. Asad Khan, Kiran Dixit, Moinuddin and Khursheed Alam
Bladder cancer is a disease of continuing public health significance. Some known risk factors for bladder cancer development include smoking, occupational exposure, genetic susceptibility, infectious diseases and radiation therapy. Smoking and occupational exposure have strongly implicated aromatic amines as being carcinogenic for the bladder, with 4-aminobiphenyl (4-ABP) being one of the most potent. 4-ABP is a major etiological agent of human bladder cancer, and its metabolites are able to form DNA adducts that may induce mutation and initiate bladder carcinogenesis. Binding characteristics and specificity of bladder cancer anti-DNA antibodies were analyzed by direct binding and inhibition enzyme-linked immunosorbent assay. The data show preferential binding of bladder cancer antibodies to 4-ABP-NOmodified DNA in comparison with native native DNA. A band shift assay further substant.. View More»
DOI: 10.4172/2161-1009.1000279