Journal of Stem Cell Research & Therapy

Mark J Holtherman

Publications

• Research Article
  Human Peripheral Blood Stem Cells can be a Solution to Diabetes Mellitus Type 2 a Preliminary Study on 14 Patients
  Author(s): Ciro Gargiulo, Van H Pham, Huynh D Thao, Vo LH Trieu, Nguyen CD Kieu, Melvin Shiffman, Mark J Holtherman and Sergey K AityanCiro Gargiulo, Van H Pham, Huynh D Thao, Vo LH Trieu, Nguyen CD Kieu, Melvin Shiffman, Mark J Holtherman and Sergey K Aityan
  
  Background: The use of autologous peripheral stem cell (PB-SCs) in Diabetes Mellitus type 1 (type 1 DM) was described in 2007 with promising conclusion. However a similar treatment with a positive outcome on type 2 diabetes mellitus patients (type 2 DM) has not been yet reported. The goal of this study was to determine the effect of autologous PB-SCs transplantation in treatment of DM2 patient. Methods: Current study involved 14 patients with type 2 DM (aged 48 to 84 years) during a period of 180 days in our facility. Clinical variables (duration of DM, oral hypoglycemic drugs, time free from oral drugs) and laboratory variables (HbA1c, blood pressure, weight, cholesterol), mononuclear cells infused were assessed. Purified PB SCs were infused into major systemic vein (upper limbs or lower limbs) and subcutaneously in the abdomen. Follow-up is performed weekly after infusion during a per.. View More»
  DOI: 10.4172/2157-7633.1000354

  Abstract PDF