Journal of Carcinogenesis & Mutagenesis

Maria del Mar Vergel

Publications

• Research Article
  Cellular Senescence Controlled by p53 is a Barrier to Environmental Carcinogenesis
  Author(s): Maria del Mar Vergel, Sandra Muñoz-Galvan, Daniel Otero-Albiol and Amancio CarneroMaria del Mar Vergel, Sandra Muñoz-Galvan, Daniel Otero-Albiol and Amancio Carnero
  
  Cancer development in humans and animals may be caused by environmental factors. It has been estimated that approximately 80% of human tumors are generated by exposure to environmental carcinogens. The carcinogens may initiate or induce progression of tumors in several ways. Cellular senescence is a natural barrier used by cells to respond to stress. The molecular analysis of immortal clones shows alterations, either structural or epigenetic, in the genes involved in cellular senescence. It is thought that these alterations are caused directly by mutating or methylating the genes involved in cellular senescence. Therefore, understanding cellular senescence and how it can be modified by environmental carcinogens may be essential to control the increase in cancer prevalence. In the present work, we explored the role of cellular senescence barrier in the carcinogenic potential of some kn.. View More»
  DOI: 10.4172/2157-2518.1000208

  Abstract PDF