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Manu Chaudhary
Manu Chaudhary
India
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Research Article
Role of CSE1034 in Escherichia coli Biofilm Destruction
Author(s): Manu Chaudhary, Shailesh Kumar and Anurag PayasiManu Chaudhary, Shailesh Kumar and Anurag Payasi
Present study was conducted to assess the effect of ethylenediamine tetraacetic acid (EDTA); a non antibiotic adjuvant, and CSE1034, a novel antibiotic adjuvant entity in biofilm destruction of Escherichia coli, and comparing the efficacy with other drugs. We first determined the susceptibility of six antimicrobial agents against planktonic cultures, as well as sessile cells of E. coli clinical isolates, using the Clinical and Laboratory Standards Institute (CLSI) method. Subsequently, effects of EDTA alone, and drugs on bacterial curli production, adhesion, and in-vitro biofilm destruction were studied. The percentage of biofilm persistence was determined with spectrophotometry. The structural damage of biofilms was studied by scanning electron microscope. It was found that, among the drugs used, CSE1034 was the most effective against all of the E. coli clinical isolates, with MIC an.. View More»
DOI: 10.4172/1948-5948.1000100