Journal of Clinical & Experimental Pharmacology

Makboul K

Publications

• Research Article
  Comparative Study of Vitamin B Complex Combined with Alpha Lipoic Acid versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients
  Author(s): Boghdadi MA, Afify HE, Sabri N, Makboul K and Elmazar MBoghdadi MA, Afify HE, Sabri N, Makboul K and Elmazar M
  
  Objective: Diabetic Polyneuropathy (DPN) represents a major health problem as it increases morbidity affecting patients’ quality of life. Vitamin B frequently is used for treating DPN. ALPHA Lipoic Acid (ALA) seems to delay or reverse DPN. The present study compared the effect of Vitamin B complex combined with ALA versus Vitamin B in treatment of DPN in Egyptian type 2 diabetic patients. Methods: Forty type 2 diabetic patients with DPN of whom twenty received once-daily oral doses of ALA (600 mg) in combination with Vitamin B complex and the other twenty only received vitamin B complex for 12 weeks. Patients were evaluated by Michigan Neuropathy Screening Instrument (MNSI) questionnaire and Nerve Conduction Studies (NCS). Blood samples were collected for determination of Insulin Resistance and lipid abnormalities. All the previous ass.. View More»
  DOI: 10.4172/2161-1459.1000241

  Abstract PDF