Journal of Carcinogenesis & Mutagenesis

Maja Narlik-Grassow

Publications

• Research Article
  Pim1 Kinase Cooperates with Hormone Treatment to Promote Bladder and Ureteral Urothelial Hyperplasia
  Author(s): Maja Narlik-Grassow, Carmen Blanco-Aparicio, Yolanda Cecilia, Marco Perez, Sandra Muñoz-Galvan, Marta Cañamero, Oliver Renner and Amancio CarneroMaja Narlik-Grassow, Carmen Blanco-Aparicio, Yolanda Cecilia, Marco Perez, Sandra Muñoz-Galvan, Marta Cañamero, Oliver Renner and Amancio Carnero
  
  The Pim serine/threonine kinases have been shown to be overexpressed in cancer. Elevated levels of Pim1 kinase were demonstrated in human leukemia and lymphomas, as well as in solid tumors such as pancreatic, prostate and bladder cancers, and have been proposed as a prognostic marker. Although the Pim kinases have been identified as oncogenes in transgenic mouse models, they have only weak transforming abilities on their own. However, they have been shown to greatly enhance the ability of other genes or chemical carcinogens to induce tumors. To explore the role of Pim1 in bladder and ureteral urothelial cancer, we generated a conditional Pim1 transgenic mouse model and found that prostate specific antigen-(PSA)-driven Cre expression lead to transgene expression in the bladder upon (testosterone/estrogen) hormone treatment. We then explored the effect of Pim1 overexpression on hormone .. View More»
  DOI: 10.4172/2157-2518.1000161

  Abstract PDF