Luis Lizan
Spain
Research Article
Cost-effectiveness Analysis of Insulin Detemir Compared to Neutral Protamine Hagedorn (NPH) in Patients with Type 1 and Type 2 Diabetes Mellitus in Portugal
Author(s): Cristina Cardoso, Antonio RamÃrez de Arellano, Miriam Prades and Luis LizanCristina Cardoso, Antonio Ramírez de Arellano, Miriam Prades and Luis Lizan
Objectives: To estimate the short-term (1 year) cost-effectiveness of Insulin Detemir (IDet) compared with Neutral Protamine Hagedorn (NPH) insulin for Type 1 (T1DM) and Type 2 Diabetes Mellitus (T2DM) in Portugal. Methods: A short-term cost-effectiveness model was adapted to the Portuguese National Health System (NHS), to estimate the Incremental Cost-Effectiveness Ratio (ICER) of IDet vs. NPH in terms of euros per quality-adjusted life years (€/QALY) gained. Non-severe hypoglycemia (NSH) rate for both diabetes types, and weight change, only for T2DM, were the clinical benefit variables. Three scenarios were estimated in which NPH was assigned three different values corresponding to a cohort of recent insulinization and a cohort of long-run insulinization from the UK Hypoglycemia Study and from a Spanish observational study. For.. View More»
