Journal of Stem Cell Research & Therapy

Luciana R Meirelles

Publications

• Research Article
  Sinonasal Ultrastructure of the Hematopoietic Stem Cell Transplant and Chronic Graft-versus-host Disease with Rhinosinusitis
  Author(s): Érica Ortiz, Luciana R Meirelles, Afonso C Vigorito, Eulália Sakano and Ester Maria Danielli NicolaÉrica Ortiz, Luciana R Meirelles, Afonso C Vigorito, Eulália Sakano and Ester Maria Danielli Nicola
  
  Introduction: It is believed that immunosuppression is the sole cause for the occurrence of rhinosinusitis in hematopoietic stem cell transplant (HSCT). There is a high incidence of sinusitis in recipient patients, especially in those with Chronic Graft Versus Host disease (GVHD). Histopathological abnormalities were described in recipients’ sinus mucosa compared to immunocompetent patients. There were also mucosal abnormalities related to cytotoxicity in the transplanted patients with chronic GVHD but no difference in ultrastructure between HSCT patients with and without GVHD, except for increased goblet cells in patients without GVHD. The relation between the sinonasal mucosa abnormalities of these patients and rhinosinusitis is not well established yet. Objective: To verify the ultrastructure of the sinonasal mucosa of HSCT with and without GVHD with rhinosinusitis to underst.. View More»
  DOI: 10.4172/2157-7633.1000157

  Abstract PDF