Journal of Carcinogenesis & Mutagenesis

Lottini T

Publications

• Research Article
  A Mouse Model for Barrett’s Esophagus: Surgery and Histology
  Author(s): Taddei A, Lottini T, Fazi M, Ringressi MN, Lastraioli E, Bechi P and Arcangeli ATaddei A, Lottini T, Fazi M, Ringressi MN, Lastraioli E, Bechi P and Arcangeli A
  
  Purpose: Barrett’s esophagus (BE) is the sole precursor lesion of esophageal adenocarcinoma (EA) identified so far. The progression towards EA is estimated to affect 2 to 10% of BE patients, hence endoscopic surveillance of at-risk subjects is mandatory. Surveillance endoscopic procedures imply high cost, discomfort and risks for the patient, as well as the non-infrequent missing of small, focal lesions signaling progression to EA. Hence, it is important to search for new potential markers to better identify BE patients at risk of EA progression. The aim of this study was to produce a mouse model of BE, suitable for further molecular and genetic analyses. Methods: Forty-four CD1 mice were operated upon by means of an esophago-jejunal anastomosis. Five CD1 mice underwent a sham operation. The animals were sacrificed 10 months later and .. View More»
  DOI: 10.4172/2157-2518.1000304

  Abstract PDF