Journal of Stem Cell Research & Therapy

Long Wang

Publications

• Research Article
  Blockade of Autocrine TGF-ß Signaling Inhibits Stem Cell Phenotype, Survival, and Metastasis of Murine Breast Cancer Cells
  Author(s): Zhao Liu, Abhik Bandyopadhyay, Robert W. Nichols, Long Wang, Andrew P. Hinck, Shui Wang and Lu-Zhe SunZhao Liu, Abhik Bandyopadhyay, Robert W. Nichols, Long Wang, Andrew P. Hinck, Shui Wang and Lu-Zhe Sun
  
  Transforming growth factor beta (TGF-β) signaling has been implicated in driving tumor progression and metastasis by inducing stem cell-like features in some human cancer cell lines. In this study, we have utilized a novel murine cell line NMuMG-ST, which acquired cancer stem cell (CSC) phenotypes during spontaneous transformation of the untransformed murine mammary cell line NMuMG, to investigate the role of autocrine TGF-β signaling in regulating their survival, metastatic ability, and the maintenance of cancer stem cell characteristics. We have retrovirally transduced a dominant-negative TGF-β type II receptor (DNRII) into the NMuMG-ST cell to abrogate autocrine TGF-β signaling. The expression of DNRII reduced TGF-β sensitivity of the NMuMG-ST cells in various cell-based assays. The blockade of autocrine TGF-β signaling reduced the abi.. View More»
  DOI: 10.4172/2157-7633.1000116

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