Letícia de Almeida Brondani
Brazil
Review Article
Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta-Analysis
Author(s): TaÃs Silveira Assmann, Natália Emerim Lemos, Letícia de Almeida Brondani, Rodrigo Carlessi, Carmen Maldonado-Bernal, Miguel Cruz, Luis Henrique Canani and Daisy CrispimTaís Silveira Assmann, Natália Emerim Lemos, Letícia de Almeida Brondani, Rodrigo Carlessi, Carmen Maldonado-Bernal, Miguel Cruz, Luis Henrique Canani and Daisy Crispim
Objective: This paper describes a case-control study and a meta-analysis conducted to determine whether the TLR4 Asp299Gly (rs4986790) and Thr399Ile (rs4986791) polymorphisms are associated with type 2 diabetes mellitus (T2DM).
Methods: In the case-control study were enrolled 1683 T2DM patients and 584 nondiabetic subjects from Brazil. A literature search was conducted in order to identify studies that investigated associations between the referred TLR4 polymorphisms and T2DM. Pooled odds ratios (OR) were calculated for allele contrast and dominant inheritance models.
Results: In the case-control study, genotype and allele frequencies of the Asp299Gly and Thr399Ile polymorphisms differed between T2DM patients and nondiabetic subjects (P<0.05). Moreover, the presence of the minor alleles of these polymorphisms we.. View More»
