Journal of Clinical & Experimental Pharmacology

Leszek Domanski

Publications

• Research Article
  Influence of Intrauterine Exposure to Safe and Contraindicated Immunosuppressive Drugs In Combinations during Pregnancy on Morphology and Function of Kidneys in Juvenile Wistar Rats
  Author(s): Joanna Kabat-Koperska, Agnieszka Kolasa-Wolosiuk, Irena Baranowska-Bosiacka, Krzysztof Safranow, Danuta Kosik-Bogacka, Izabela Gutowska, Anna Pilutin, Edyta Golembiewska, Karolina Kedzierska, Leszek Domanski and Kazimierz CiechanowskiJoanna Kabat-Koperska, Agnieszka Kolasa-Wolosiuk, Irena Baranowska-Bosiacka, Krzysztof Safranow, Danuta Kosik-Bogacka, Izabela Gutowska, Anna Pilutin, Edyta Golembiewska, Karolina Kedzierska, Leszek Domanski and Kazimierz Ciechanowski
  
  Abstract Objective: In the study we focused on the impact of ?safe? and ?contraindicated? immunosuppressive drugs in combinations during pregnancy on changes in native kidneys in juvenile Wistar rats after exposure of pregnant female rats to these drugs. Method: The study was conducted on 32 female (full dose of drugs) and 8 female Wistar rats (half dose of drugs), subjected to immunosuppressive regimens commonly used in therapy of human kidney transplant recipients. The animals received drugs by oral gavage 2 weeks before pregnancy and during 3 weeks of pregnancy. Results: Basing on serum creatinine concentrations, combination of tacrolimus, mycophenolate mofetil and prednisone turned out to be less harmful to the kidney than combination of cyclosporine A, mycophenolate mofetil and prednisone or cyclosporine A, everolimus and prednisone. Neutrophil-gelatinase associated lipocalin (NGAL).. View More»
  DOI: 10.4172/2161-1459.1000196

  Abstract PDF