Laura A Woollett
Tanzania
Research Article
Exercise Improves Glucose Disposal and Insulin Signaling in Pregnant Mice Fed a High Fat Diet
Author(s): Lindsay G Carter, Sara Y Ngo Tenlep, Laura A Woollett and Kevin J PearsonLindsay G Carter, Sara Y Ngo Tenlep, Laura A Woollett and Kevin J Pearson
Objective: Physical activity has been suggested as a non-pharmacological intervention that can be used to improve glucose homeostasis in women with gestational diabetes mellitus. The purpose of this study was to determine the effects of voluntary exercise on glucose tolerance and body composition in pregnant high fat diet fed mice. Methods: Female mice were put on a standard diet or high fat diet for two weeks. The mice were then split into 4 groups; control standard diet fed, exercise standard diet fed, control high fat diet fed, and exercise high fat diet fed. Exercise mice had voluntary access to a running wheel in their home cage one week prior to mating, during mating, and throughout pregnancy. Glucose tolerance and body composition were measured during pregnancy. Akt levels were quantified in skeletal muscle and adipose tissue isolated from saline or insulin injected pregnant da.. View More»
