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Kazumi Fujioka
Kazumi Fujioka
Department of Dermatology,
Fujioka Dermatological Clinic, Tokyo
Japan
Publications
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Review Article
Propensity to the Vascular Smooth Muscle Cell Abnormality in Migraine without Aura and Vasospastic Angina along with a Genome-Wide Association Studies
Author(s): Kazumi FujiokaKazumi Fujioka
A different genetic susceptibility contribution in migraine without aura (MWOA) and migraine with aura (MWA) has been suggested in the study using a genetic risk score (GRS). Even though epidemiologic studies reveal that comorbidity with coronary artery disease (CAD) is more common in MWA than MWOA, it has been reported that MWOA had a genetic overlap with CAD, whereas MWA did not. The author has reported that patients with MWOA in the interictal period have a selective sensitivity in dilator response to nitroglycerin (NTG) and may have systemic nitric oxide (NO) sensitivity to NTG as previously described. The result indicated a vascular smooth muscle cell (VSMC) abnormality. Meanwhile, it has been provided that migraine-associated genes were involved in both arterial and smooth muscle function in genome-wide association studies (GWAS) profiles. The author emphasizes that VSMC abnorma.. View More»