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Katsumi Uoshima
Katsumi Uoshima
Japan
Publications
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Research Article
Valproic Acid Contributes to Bone Cavity Healing in Rats
Author(s): Mamunur Rashid, Yosuke Akiba, Kaori Eguchi, Nami Akiba, Masaru Kaku, Masako Nagasawa and Katsumi UoshimaMamunur Rashid, Yosuke Akiba, Kaori Eguchi, Nami Akiba, Masaru Kaku, Masako Nagasawa and Katsumi Uoshima
Background: Sufficient bone quality and quantity are necessary for successful results in a dental implant. Although numerous bone augmentation methods have been reported, used in the clinic and showed successful results in some extent, more reliable methods are still required. Valproic Acid (VPA) which was known as an Antiepilepsy agent and histone deacetylases inhibitor regulate osteoblast differentiation through Runx2 activation in vitro. The present study aimed to evaluate the effects of systemic administration of VPA on bone regeneration in rat maxillary bone cavity. Material and Methods: Fifty-four Wistar rats were used for the experiment. Upper first and second molars were extracted at 4 weeks. Three weeks after extraction, the experimental group received intraperitoneal (IP) injection of VPA and control group received IP inje.. View More»