Journal of Liver

Jürgen Kopitz

Publications

• Research Article
  Surgery under Propofol Anesthesia Induced Behavioral Changes Associated With Increased Cerebral Apoptosis in Rats
  Author(s): Konstanze Plaschke, Julia Schneider and Jürgen KopitzKonstanze Plaschke, Julia Schneider and Jürgen Kopitz
  
  It is not known whether prolonged propofol anesthesia and/or surgery are responsible for postoperative cerebral deterioration, including Alzheimer-like histological changes, apoptosis and cognitive dysfunction. Therefore, the aim of the present study was to use partial liver resection as a surgical rat model in middle-aged rats in order to distinguish postoperative cerebral changes brain from those in rats after propofol anesthesia without surgery. In this randomized, controlled study, behavioral changes were investigated in n=36 rats (12- to 14-month-old) using the hole board test system and Morris water maze. Cerebral glycogen synthase kinase-3ß (GSK-3ß) and tau protein were analyzed using ELISA technique. Cerebral amyloid was determined using congo red staining with subsequent fluorescence analysis. Apoptosis in rat brain was analyzed using TUNEL test and casp.. View More»
  DOI: 10.4172/2167-0889.1000136

  Abstract PDF