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José Manuel Lozano
José Manuel Lozano
Head of the Biocatalysis Department, Fundacion Instituto de Inmunologia de Colombia (FIDIC), Carrera 50 No. 26-20, ZIP Code 020304, Bogota DC,
Colombia
Publications
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Research Article
Cationic Peptides Harboring Antibiotic Capacity is Selective for Leishmania Panamensis and Leishmania Major
Author(s): José Manuel Lozano, Bernarda Soraya Cuadrado, Gabriela Delgado and Manuel Elkin PatarroyoJosé Manuel Lozano, Bernarda Soraya Cuadrado, Gabriela Delgado and Manuel Elkin Patarroyo
The fairly recent appearance of Leishmania resistance to currently-used therapy has led to the search for new therapeutic strategies. This work was thus aimed at evaluating the in vitro effect of 16 cationic synthetic antimicrobial peptides’ antileishmanial and haemolytic activity. The viability of murine (J774) and human (U937), peripheral blood monocytes, HeLa and HepG2 cells and L. (V) panamensis and L. (L) major promastigotes was then ascertained using the aforementioned peptides. All antimicrobial peptides were synthesised and each cell and parasite line was treated with different peptide concentrations. Melittin, bombinin, mastoparan 8 (MP-8), MP-X and dermaseptin-S1 reduced potential human and murine host cells’ viability at greater concentrations than pentamidine isethionate, human peripheral blood and U937 monocytes being the most sensitive to peptide action. Meli.. View More»
DOI: 10.4172/1948-5948.1000122