Journal of Allergy & Therapy

John A Donnie

Publications

• Research Article
  Comparative Immunomodulatory Activity of Ascaris Suum Eggs and Dermatophagoides pteronyssinus Extract in BALB/C Mice: Cytokine and Immunoglobulin Regulations
  Author(s): Pineda Maria Ruth B*, Ramos and John A DonniePineda Maria Ruth B*, Ramos and John A Donnie
  
  Allergy is highly prevalent in well-developed countries; hygiene hypothesis suggests that this is due to exposure to previous bacterial infection eliciting Th1-response that suppresses Th2-mediated responses. Aside from Th2 suppressing Th1-responses, Th2-mediated infections such as parasitism, appear to lower the risk of developing allergy. This study investigates the effects of Ascaris suum infection in Dermatophagoides pteronyssinus-induced allergic BALB/c mice. Ninety BALB/c mice divided into three trials were randomly grouped into: normal control (1), A. suum infected mice (2), D. pteronyssinus exposed mice (3), A. suum infected mice and then exposed to D. pteronyssinus (4), D. pteronyssinus exposed mice and then infected with A. suum (5), and mice exposed and infected with D. pteronyssinus and A. suum, simultaneously (6). Blood and fecal samples were collected at days 0, 36, and .. View More»
  DOI: 10.4172/2155-6121.1000119

  Abstract PDF