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Jiuli Zhang
Jiuli Zhang
Tanzania
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Research Article
Methionine Sulfoxide Reductase A Mediates Dietary Restriction-Induced Lifespan Extension in Caenorhabditis elegans
Author(s): Justin Minnerly, Jiuli Zhang, Rebeca Aldunate, Herbert Weissbach and Kailiang JiaJustin Minnerly, Jiuli Zhang, Rebeca Aldunate, Herbert Weissbach and Kailiang Jia
Background: Methionine sulfoxide reductase A (MsrA) is a well-studied antioxidant enzyme that has been found to be important for protecting cells against oxidative damage and regulating lifespan in several species. However, the role of MsrA in dietary restriction has not been examined. The authors evaluated the function of MsrA in dietary restriction-induced lifespan extension in Caenorhabditis elegans. Methods: C. elegans loss-of-function msra mutant animals and wild type control animals were subjected to two widely used dietary restriction treatments, solid dietary restriction (sDR) and dietary restriction by liquid bacteria (BDR). The survival of the animals was evaluated and the data was statistically analyzed. Results: The loss-of-function mutation of msra significantly suppressed the lifespan extensi.. View More»
DOI: 10.4172/2329-8847.1000110