Journal of Stem Cell Research & Therapy

Jian Zhang

Publications

• Research Article
  Histone Deacetylase Inhibitors can Repress Proliferation and Induce Apoptosis in Gingiva Progenitor Cells from Idiopathic Gingival Fibromatosis
  Author(s): Zhi Jia, Chunyue Feng, Yingchenyao Wang, Jingkun Li, Tingting Zhang, Jian Zhang and Dayong LiuZhi Jia, Chunyue Feng, Yingchenyao Wang, Jingkun Li, Tingting Zhang, Jian Zhang and Dayong Liu
  
  Objective: Idiopathic gingival fibromatosis (IGF), which is characterized by diffuse enlargement of the gingiva due to expansion and accumulation of connective tissue, is a relatively rare hereditary condition that has no specific cause. The aim of this study was to investigate whether the anti-tumor drugs trichostatin A (TSA; inhibits histone deacetylase) and panobinostat (LBH589; a non-selective inhibitor of histone deacetylase) inhibit the proliferation of cells derived from gingiva in patients with IGF. Materials and methods: After osteogenic differentiation and adipogenic induction, the differences between normal gingival mesenchymal stem cells ( N-GMSCs ) and hyperplastic gingival mesenchymal stem ( H-GMSCs, theI cells from IGF ) were determined in terms of alkaline phosphatase staining and activity, alizarin red staining.. View More»
  DOI: 10.4172/2157-7633.1000327

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