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Jian Cao
Jian Cao
Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases,
Beijing 100853
China
Publications
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Review Article
EET Intervention on HO-1 Prevent Obesity Derived Cardiovascular Diseases
Author(s): Lu Liu, Xin Huang, Jinliao Gao, Yusong Guo, Yanqi Di, Shasha Sun and Jian CaoLu Liu, Xin Huang, Jinliao Gao, Yusong Guo, Yanqi Di, Shasha Sun and Jian Cao
The increase in the prevalence of obesity represents a worldwide phenomenon and is correlated with several metabolic and cardiovascular diseases, and cardiovascular disease remains the leading cause of death worldwide. And epoxyeicosatrienoic acid (EET), correlated with heme oxygenase (HO), with emerge to be a promising strategy for pharmacological mediation. Moreover, inhibit soluble epoxide hydroxylase (sEH), the enzyme converts EET to less potent metabolite, could upregulate EET concentration, which could upregulate HO-1, working together to reduce inflammation and increase vasodilation, in order to improve endothelial and cardiac function. The EET-HO pathway has been indicated as a most potent target for reversing oxidative stress and pre-adipocyte differentiation, so as to moderate oxidative capacity in mitochondrial dysfunction. While EET agonists and sEH inhibitors are becoming.. View More»
DOI: 10.4172/2167-7956.1000163