Journal of Neonatal Biology

Journal of Neonatal Biology
Open Access

ISSN: 2167-0897


Jessica L Burnside

  • Rapid Communication
    Periostin Expression is Altered in Aortic Valves in Smad6 Mutant Mice
    Author(s): Yukiko Sugi, Michael J Kern, Roger R Markwald and Jessica L BurnsideYukiko Sugi, Michael J Kern, Roger R Markwald and Jessica L Burnside

    Smad6 is known to predominantly inhibit BMP signaling by negatively regulating the BMP signaling process. Therefore, Smad6 mutation potentially provides an important genetic model for investigating the role of BMP signaling in vivo. Periostin is a 90-kDA secreted extracellular matrix (ECM) protein and implicated in cardiac valve progenitor cell differentiation, maturation and adult aortic valve calcification in mice. We have previously reported periostin expression patterns during AV valve development in mice. Because periostin can play critical roles in aortic valve interstitial cell differentiation and can be correlated with adult valve disease pathogenesis, in the present study we specifically focused on periostin expression during outflow tract (OT) development and its expression within the adult mouse valves. We previously reported that periostin expression in valve progenitor ce.. Read More»
    DOI: 10.4172/2167-0897.1000101

    Abstract PDF

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