Journal of Carcinogenesis & Mutagenesis

Jeffrey D. Laskin

Publications

• Research Article
  Parametrial Fat Tissue from High Fat Diet-Treated SKH-1 Mice Stimulates Transformation of Mouse Epidermal JB6 Cells
  Author(s): Jamie J. Bernard, You-Rong Lou, Qing-Yun Peng, Tao Li, Priyal R. Vakil, Ning Ding, Jeffrey D. Laskin, Zigang Dong, Allan H.Conney and Yao-Ping LuJamie J. Bernard, You-Rong Lou, Qing-Yun Peng, Tao Li, Priyal R. Vakil, Ning Ding, Jeffrey D. Laskin, Zigang Dong, Allan H.Conney and Yao-Ping Lu
  
  Our previous studies indicated that decreasing visceral adipose tissue by surgical removal of the parametrial fat pads inhibited UVB-induced carcinogenesis in SKH-1 mice fed a high fat diet (HFD), but not a low fat diet (LFD) indicating that the parametrial fat tissue from mice fed a HFD played a role in skin carcinogenesis. Objective: In the present study, we sought to investigate how a HFD may influence the intrinsic properties of the parametrial fat tissue to influence UVB-induced skin tumor formation. Methods and Results: Immunohistochemical staining, adipokine array, and flow cytometry showed that parametrial fat tissue from mice fed a HFD had a higher density of macrophage-fused dead adipocytes (crownlike structures), more adipokines, and stimulated the production of more reactive oxygen species compared with parametrial fat tissue from mice fed a LFD. These differences between .. View More»
  DOI: 10.4172/2157-2518.1000183

  Abstract PDF