Journal of Carcinogenesis & Mutagenesis

Javid J

Publications

• Research Article
  TP53 is a Mutational Target in Non Small Cell Lung Cancer Patients and its Pro/Pro Variant is Potentially Contributing to Cancer Susceptibility
  Author(s): Saxena Alpana, Javid J, Mir R, Masroor M, Ahamad I, Farooq S, Yadav P, Zuberi M, Ajaz Ah Bhat, Ahmad I, Khalanin T, Julka PK, Mohan A, Lone M, Banday MA and Ray PCSaxena Alpana, Javid J, Mir R, Masroor M, Ahamad I, Farooq S, Yadav P, Zuberi M, Ajaz Ah Bhat, Ahmad I, Khalanin T, Julka PK, Mohan A, Lone M, Banday MA and Ray PC
  
  Background: TP53 is one of the most important tumor suppressor genes, regulating various cellular processes and playing a pivotal role in preventing a cell to become malignant. P53 mutant protein containing arginine or proline at codon 72 shows different biological and biochemical activity. So, the aim of the present study was to find out the role of mutated P53 gene with different codon 72 variants on the clinical outcome of patients suffering from NSCLC.Materials and methods: A case control study of 100 NSCLC patients and 100 cancer free healthy controls was performed. TP53 codon 72 polymorphism and mutations at exon 5 and 8 were analyzed in NSCLC patients using AS–PCR and survival curves were plotted using Kaplan–Meier analysis.Results: A statistically significant difference was observed in the frequencies o.. View More»
  DOI: 10.4172/2157-2518.1000138

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