Journal of Carcinogenesis & Mutagenesis

Jan Kornafel

Publications

• Research Article
  Tagging Snps in the Excision Repair Cross-Complementing Group 4 (ERCC4)Gene Increased Risk of Cervical Squamous Cell Carcinoma (CSCC) and Modulate the Disease Outcome
  Author(s): Edyta Pawlak-Adamska, Magdalena Bartosinska, Iwona Wlodarska-Polinska, Agnieszka Ignatowicz-Pacyna, Jan Kornafel, Marcin Stepien, Iwona Ewa Kochanowska and Irena FrydeckaEdyta Pawlak-Adamska, Magdalena Bartosinska, Iwona Wlodarska-Polinska, Agnieszka Ignatowicz-Pacyna, Jan Kornafel, Marcin Stepien, Iwona Ewa Kochanowska and Irena Frydecka
  
  Background: Given the important role of ERCC4 gene in multiple DNA repair systems, we hypothesized that genetic variations within this gene may be a cervical squamous cell carcinoma (CSCC) risk and disease modulatory factor.Methods: In population-based, case-control association study including 143 CSCC patients and 207 healthy women, two ERCC4tagSNPs were studied.Results: A significant protective effect against CSCC was observed assuming a dominant model in case of ERCC4rs3136176 ([AA]+[AT]vs.[TT]: p=0.04,OR=0.43), and genotype [AA] strongly protects against poorly (G3) differentiated CSCC (pcorreced=0.008,OR=0.15) and significantly increased the disease remission rate (p=0.05,OR=0.48).A statistically significant increase frequency of ERCC4rs1799798 [A] allele was seen i.. View More»
  DOI: 10.4172/2157-2518.1000172

  Abstract PDF