Clinical & Medical Biochemistry

Jacqui Coombes

Publications

• Research Article
  Longitudinal Changes in Thyroid Hormones During Conception Cycles and Early Pregnancy
  Author(s): Kristina Hamilton, Narelle Hadlow, Peter Roberts, Patricia Sykes, Allison McClements, Jacqui Coombes and Phillip MatsonKristina Hamilton, Narelle Hadlow, Peter Roberts, Patricia Sykes, Allison McClements, Jacqui Coombes and Phillip Matson
  
  Objective: The aim of this study was to characterize changes in free triiodothyronine (fT3), free thyroxine (fT4) and thyroid-stimulating hormone (TSH) during the follicular and luteal phase and during subsequent early pregnancy in individual women. Method: TPOAb negative women with a viable pregnancy (n=49) had fT3, fT4 and TSH measured longitudinally in serum samples at baseline/non-pregnant (gestation week 0), ovulation (gestation week 2), mid-luteal phase (gestation week 3) and twice weekly from gestation weeks 4 to 6.5. Patient groups received in their conception cycle either no medication (n=13), low ovarian stimulation, (n=17) or controlled ovarian hyperstimulation (COH) for IVF treatment (n=19). Results: Women receiving COH had a transient drop in TSH at the time of ovulation followed by a peak at midluteal.. View More»
  DOI: 10.4172/2471-2663.1000125

  Abstract PDF