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Hui Zhao
Hui Zhao
Department of Integrative Medicine and Neurobiology, National Key Lab of Medical Neurobiology, Institute of Brain Sciences,
Shanghai
China
Publications
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Research Article
Distinctive VEGFR2 Endocytic Delivery during Muscle Mobilization
Author(s): Han-Wei Huang and Hui ZhaoHan-Wei Huang and Hui Zhao
Denervation of skeletal muscles initiates a cascade of cellular events that can lead to muscle atrophy, however, the underlying mechanism is controversial. In the present study, by using techniques including real-time PCR, immunoblotting, fluorescent in situ hybridization, and enzyme-linked immunosorbent, we demonstrated that VEGFR2 was distinctively cross-linked with MyHCI in gastrocnemius, and MyHC2B in soleus, which was likely responsible for activation of receptor tyrosine kinases including growth factor receptor-bound 2, phospholipase Cγ, p85, Vav, and human epidermal growth factor receptor 2. When challenged with muscle mobilization, in gastrocnemius, VEGFR2 was preferentially translocated into mitochondria, which resulted in activation of NAD+ - SIRT1 and remodel of macrophage polarization. Alternatively, in soleus, VEGFR2 was targeted to ER, this shortrange transport eve.. View More»
DOI: 10.4172/2161-1459.1000177