Journal of Carcinogenesis & Mutagenesis

Hiromi Nakamura

Publications

• Research Article
  Dedifferentiation of Epithelial Tumors Enhances Cytotoxicity, Survival and Expansion of Allogeneic CD8+ T Cells and Natural Killer Cells
  Author(s): Anahid Jewett, Hiromi Nakamura, Meiying Wang, Antonia Teruel, Avina Paranjpe and Marcela RomeroAnahid Jewett, Hiromi Nakamura, Meiying Wang, Antonia Teruel, Avina Paranjpe and Marcela Romero
  
  Our recent findings have suggested an important role for the conditioning of Natural Killer cell effector function by the cancer stem cells as well as healthy untransformed stem cells, stromal monocytes and fibroblasts in cellular differentiation and tissue regeneration. We have also reported that de-differentiation or reversion of tumor cells or healthy non-transformed cells to a less-differentiated stage activated cytotoxic function of NK cells. In this report we examined the function of allogeneic CD8+ T cell cytotoxic function against de-differentiated tumors to determine whether induction of cytotoxic function by de-differentiated tumors is unique to the function of NK cells or that the cytotoxic function of CD8+ T cells is similarly induced when cultured with NFκB knock down tumors. Here, we demonstrate that dedifferentiation of tumors by the inhibition of NFκB nucle.. View More»
  DOI: 10.4172/2157-2518.S1-007

  Abstract PDF