Hiroaki Shimomura
Japan
Research Article
Combination Therapy of Pitavastatin and Sitagliptin Improves the Estimated Glomerular Filtration Rate in Patients with Type 2 Diabetes
Author(s): Soichi Kurioka, Yasuo Ohyama, Akira Ichibangase, Hideho Murata, Nobuhiko Kataoka, Hiroaki Shimomura, Hideaki Sawaki, Tamaki Imai and Shinichiro OhashiSoichi Kurioka, Yasuo Ohyama, Akira Ichibangase, Hideho Murata, Nobuhiko Kataoka, Hiroaki Shimomura, Hideaki Sawaki, Tamaki Imai and Shinichiro Ohashi
Objective: Previous studies have shown that statins improve kidney function in patients with chronic kidney disease. In this study, we examined the effect of combination therapy (statin and dipeptidylpeptidase IV inhibitor) on kidney function in patients with type 2 diabetes with hypercholesterolemia. Research design and methods: The subjects were 81 patients with type 2 diabetes with hypercholesterolemia, of whom 29 were treated with 50 mg sitagliptin (combination therapy group) and 52 did not receive sitagliptin (control group). The patients received 2 mg pitavastatin for 6 months and the effects on estimated glomerular filtration rate (eGFR), lipid profile, and glycemic control were evaluated. Results: After 6 months of pitavastatin treatment, there was a significant increase in eGFR in the combination therapy group (71.3 ± 23.2 to 84.2 &plu.. View More»
