Journal of Pharmacogenomics & Pharmacoproteomics

Harrison Leong

Publications

• Research Article
  A High-throughput Real-time PCR Approach to Pharmacogenomics Studies
  Author(s): Toinette Hartshorne, Ferrier Le, Jordan Lang, Harrison Leong, Kathleen Hayashibara, Dominique Dewolf, James Elliot and Elliot SheltonToinette Hartshorne, Ferrier Le, Jordan Lang, Harrison Leong, Kathleen Hayashibara, Dominique Dewolf, James Elliot and Elliot Shelton
  
  Advances in personalized medicine have led to an increase in pharmacogenomics studies that involve testing individuals for drug metabolism enzyme and transporter gene polymorphisms implicated in drug response. As a consequence, there is a growing demand for affordable, easy to use technologies with fast sample-to-results workflows that can accommodate testing customizable sets of target gene variants and a changeable number of samples. Additionally, data analysis tools are needed to facilitate translation of an individual’s genetic information to their diploid content of gene-level star allele haplotypes, which can be correlated with drug metabolism enzyme phenotypes. Here we describe the development of a comprehensive pharmacogenomics experiments workflow solution to meet this need. High quality data was generated from purified buccal swab DNAs run with TaqMan® SNP genotypi.. View More»
  DOI: 10.4172/2153-0645.1000133

  Abstract PDF