Journal of Neonatal Biology

Guo Jia-jia

Publications

• Research Article
  Intrauterine Subclinical Inflammation Sensitizes Hypoxic Ischemia- Induced Injury in the Immature Rat Brain and the Mechanisms
  Author(s): Xu Fa-lin, Zhang Yan-hua and Guo Jia-jiaXu Fa-lin, Zhang Yan-hua and Guo Jia-jia
  
  Objective: To investigate whether intrauterine subclinical infection sensitizes HI-induced brain injury in the immature rat, the changes and significance of Histone deacetylases (HDACs) in brain injury, and the effects of erythropoietin on White Matter injury. Methods: Pregnant SD rats at gestation day 15 were injected LPS (0.3 mg/kg) or sterile saline (N.S) intraperitoneally, continue to rise until delivery. Rat pups on postnatal (P) days 5 were randomly assigned into 4 groups: control group, LPS, HI, LPS+HI group. Intervention groups included LPS+HI+N.S group and LPS+HI+EPO group. Brain tissues were observed on the time point of 6 h, 24 h and 7d after 40-minHI. The expression of TNF-α and HDACs in the brain homogenate were measured by ELISA. The level of MBP and MAP-2 were detected by immunohistochemistry staining. The expression of MAP.. View More»
  DOI: 10.4172/2167-0897.1000126

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