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Gihan E-H Gawish
Gihan E-H Gawish
P.O. Box V6T 1Z4, Vancouver
Canada
Publications
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Research Article
Molecular Characterization of Factor V Leiden G1691A and Prothrombin G20210A Mutations in Saudi Females with Recurrent Pregnancy Loss
Author(s): Gihan E-H Gawish and Osama Al-KhameesGihan E-H Gawish and Osama Al-Khamees
Recurrent pregnancy loss (RPL) is the most common complication of pregnancy in Saudi Female. Approximately 18% of all clinically recognized pregnancies are spontaneously aborted. Although several causes of RPL have been established, more than 50% of cases remain unexplained. Recently, thrombophilias have been suggested as a possible cause of RPL. Factor V Leiden (FVL) (G1619A) and Factor II (prothrombin) (G20210A) gene mutations are the most common types of hereditary thrombophilias, but are usually undiagnosed because most carriers are asymptomatic. The aim of this study was to investigate two common mutations of the factor V Leiden (G1619A) and factor II Prothrombin (G20210A) gene mutations and to assess whether recurrent pregnancy loss patterns among Saudi women differ according to causal/associated conditions. The study including 142 females, 72 had a history of 2.. View More»
DOI: 10.4172/2155-9864.1000165