Journal of Clinical & Experimental Pharmacology

George Kouvatseas

Publications

• Research Article
  Expression of Notch Receptors in Primary Breast Cancer and Correlation with Pathological Features
  Author(s): Panagiota Touplikioti, Dafni Chondronasiou, Fani Ziouti, Melanie Koubanaki, Konstantinos Haitoglou, George Kouvatseas and Konstantinos T. PapazisisPanagiota Touplikioti, Dafni Chondronasiou, Fani Ziouti, Melanie Koubanaki, Konstantinos Haitoglou, George Kouvatseas and Konstantinos T. Papazisis
  
  Introduction: Notch signaling evolves as an important mediator of stem cell biology, tumor formation, angiogenesis and cell fate decisions. Four Notch receptors and five ligands have been identified in human, and they regulate a complex signal transduction pathway that interacts with other stem cell-related pathways as Sonic Hedgehog and Wnt. Recently, dysregulation of Notch pathway has been found to play a crucial role in breast cancer oncogenesis and it could serve as a target for treatment. Methods: We estimated the expression of Notch receptors? at the mRNA level, in 200 human breast cancer samples from a single institution in Northern Greece. Notch 1-4 mRNA was estimated by using Real-time PCR and we correlated the level of Notch expression with breast cancer pathology (TNM, grade oestrogen and progesterone receptors and HER2). Results: We found that Notch receptors (at the mRNA lev.. View More»
  DOI: 10.4172/2161-1459.1000109

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