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Gamal Al-Shazli
Gamal Al-Shazli
Saudi Arabia
Publications
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Research Article
Development of Novel Controlled Release Gliclazide-Loaded poly(ε- caprolactone) Microparticles: Effect of Polymer Blends
Author(s): Nahla S Barakat, Gamal Al-Shazli and Azza H AlmedanyNahla S Barakat, Gamal Al-Shazli and Azza H Almedany
Gliclazide-loaded microparticles made with a polymeric blend were prepared by a solvent evaporation technique. Organic solutions of two polymers, poly (epsilon-caprolactone) (PCL) and Eudragit RS (E RS) or ethyl cellulose (EC), in different weight ratios, and 33.3% of GLZ were prepared and dropped into aqueous solution of poly vinyl alcohol, in different experimental conditions, achieving drug-loaded microparticles. The obtained microparticles were characterized in terms of yield of production, shape, size, surface properties, drug content, and in vitro drug release behavior. The physical state of the drugs and the polymer was determined by scanning electron microscopy (SEM), Fourier transform infra red and differential scanning calorimetry (DSC). Following the in vitro release studies microparticles made from blends of polymer, PCL/E RS or EC showed slower drug release than micropart.. View More»
DOI: 10.4172/2153-2435.1000150