Journal of Psychiatry

Gaha Lotfi

Publications

• Research Article
  Association between Paraoxonase 1 (PON1) and Suicidal Risk in Patients with Schizophrenia
  Author(s): Mensi Rym, Messaoud Ame, Hellara Ilhem, Amamou Badii, Neffati Fadoua, Douki Wahiba, Najjar Mohamed Fadhel and Gaha LotfiMensi Rym, Messaoud Ame, Hellara Ilhem, Amamou Badii, Neffati Fadoua, Douki Wahiba, Najjar Mohamed Fadhel and Gaha Lotfi
  
  Background: There have been many studies on psychiatric disorders, but very little is known about the biology of suicide with schizophrenia. In the present study, we are looking for a possible connection between paraoxonase 1 (PON1) and suicidal behavior in schizophrenic Tunisian patients. Methods: Assay of PON1 has been done for 170 schizophrenic patients with and without suicide attempts and 119 healthy controls. All patients enrolled in the study were evaluated by psychometric scales (PANSS, EGF, CGI, BPRS and CALGARY). Results:In our study, a significant decrease in the enzymatic activity of PON1 was found in schizophrenia patients compared to controls. PON1 was also significantly lower in schizophrenic patients with suicide attempt compared to those without suicide attempt. In our work, a weak correlation between the psychometric scale CGI severity of the disease, PON1 activity a.. View More»
  DOI: 10.4172/2378-5756.1000424

  Abstract PDF