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Fazlul H. Sarkar
Fazlul H. Sarkar
Barbara Ann Karmanos Cancer Institute,
740 Hudson Webber Cancer Research Center, 4100 John R, Detroit, MI 48201
Tanzania
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Review Article
Evolving Concept of Cancer Stem Cells: Role of Micro-RNAs and their Implications in Tumor Aggressiveness
Author(s): Seema Sethi and Fazlul H. SarkarSeema Sethi and Fazlul H. Sarkar
Recent advances in cancer stem cell (CSC) research and the role of miroRNAs (miRNAs) provided renewed interest, as supported by some convincing data showing that deregulation of miRNAs are important molecular events in the maintenance of CSC niche, which contribute to therapeutic resistance, resulting in treatment failure. Therefore, we are succinctly providing state-of-the-art knowledge on miRNAs that are associated with CSCs in this article, and it is quite clear that CSCs and miRNAs are implicated in therapeutic resistance, suggesting that novel approaches must be devised to eliminate CSCs or drug resistant cells focusing on overcoming therapeutic resistance. This indeed could be achieved by targeted strategies either to re-express the lost miRNAs or inactivate over-expressed miRNAs in cancers in general and CSCs in particular. We sincerely hope that this article would be education.. View More»
DOI: 10.4172/2157-2518.S1-005