Journal of Stem Cell Research & Therapy

Fazlul H. Sarkar

Publications

• Review Article
  Lung Cancer Stem Cells: Current Progress and Future Perspectives
  Author(s): Rasha Salama, Joy Tang, Shirish M. Gadgeel, Aamir Ahmad and Fazlul H. SarkarRasha Salama, Joy Tang, Shirish M. Gadgeel, Aamir Ahmad and Fazlul H. Sarkar
  
    Cancer stem cells (CSCs) have attracted a lot of interest in the field of cancer research in recent years. Lung CSCs share many characteristics with the normal pluripotent stem cells, such as self-renewal and multi-potent abilities. Identification of normal adult lung stem cells and their response to injury has led us to the lung cancer stem cells, partially based on the knowledge that lung CSCs as well as the normal lung stem cells share similar markers and/or location in the airway tree. Several studies have identified CD133, CD44, ALDH (aldehyde dehydrogenase) and ABCG2 (ATP-binding cassette sub-family G member 2) as lung cancer stem cell markers, all of which are validated CSC markers in multiple other cancer types as well. Embryogenesis signaling pathways, such as the hedgehog, wnt and notch pathways has also been implicated as determinants of lu.. View More»
  DOI: 10.4172/2157-7633.S7-007

  Abstract PDF