Journal of Clinical & Experimental Pharmacology

Ezim OE

Publications

• Research Article
  Antiplasmodial Effect of Ethanol Extract of Morinda lucida and Mucuna pruriens Leaves on NK65 Chloroquine Resistant Strain of Plasmodium berghei in Mice
  Author(s): Idih FM, Ighorodje-Monago CC and Ezim OEIdih FM, Ighorodje-Monago CC and Ezim OE
  
  The study evaluated the Antiplasmodial effect of ethanol extract of Morinda lucida (M.L) and Mucuna pruriens (M.P) leaves administered in combination on NK65 chloroquine resistant strain of Plasmodium berghei in mice. Chloroquine (CQ) and artemisinin combination therapy (ACT) were used as standard drugs while the drug vehicle (water) was used as the negative control. The experimental animals divided into 5 groups; group 1=Negative control (water), group 2=Chloroquine (10 mg/kg), group 3=ACT-Artemeter/Lumefantrine (20 mg/120 mg/kg), group 4=M.L +M.P (250 mg/kg), group 5=M.L+M.P (500 mg/kg). There was no decrease in percentage parasitemia of chloroquine treated group, however, there was a continuous significant decrease (p<0.05) in the group treated with ACT. Administration of M.L and M.P in sequence was found to be more effective at the dose of 500 mg/kg where it continuously and si.. View More»
  DOI: 10.4172/2161-1459.1000234

  Abstract PDF