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Elizabeth Ratcliffe
Elizabeth Ratcliffe
Postdoctoral Research Associate, Healthcare Engineering Research Group, Centre for Biological Engineering, Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU,
United Kingdom
Publications
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Research Article
Staphylococcus aureus Binding Proteins for Prevention of Orthopaedic Implant-Related Infections
Author(s): Elizabeth RatcliffeElizabeth Ratcliffe
Orthopaedic implant infections are an increasing problem and management commonly involves implant removal with serious consequences. Biofilm-forming staphylococci are the most common causative organisms, with Staphylococcus aureus being the most virulent and MRSA increasingly involved. Initial bacterial adhesion is a crucial event in biofilm formation and infection establishment. Directing host antibody against bacterial factors involved in adhesion and biofilm formation may significantly inhibit infection establishment on biomaterials. Two recombinant S. aureus-derived binding proteins (FnBP, IsdA) were investigated as potential vaccine antigens and resultant antibody was assessed to determine whether immune inhibition of bacteria-ligand binding can significantly impact on attachment to plasma-conditioned biomaterial surfaces, in the presence of other bacterial ligands. Adhesion of h.. View More»
DOI: 10.4172/1948-5948.1000160