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Dimova C
Dimova C
Macedonia
Publications
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Research Article
Gene Polymorphism of Matrix Metalloproteinase-1 in Chronic Periapical Lesions
Author(s): Evrosimovska B, Dimova C and Popovska MEvrosimovska B, Dimova C and Popovska M
Background/Aim: Matrix metalloproteinases (MMPs) are zinc and calcium dependent enzymes capable of degrading almost all extracellular matrix and basement membrane components. This group of proteolytic enzymes is believed to be implicated in the breakdown of extracellular matrix in normal physiological processes, as well as playing an important role in many destructive pathological oral processes, such as periodontal tissue destruction, root caries, tumor invasion, and chronic periapical inflammation (CPL). The aim of this study was to analyze polymorphism in the gene MMP-1 and their association and influence on clinical manifestation of chronic periapical lesions in order to provide new advances regarding the involvement of MMPs in various oral diseases associated with the inflammatory process. Materials and methods: A total of 240 unrelated Macedonian subjects were included in the pr.. View More»