Journal of Blood Disorders & Transfusion

Journal of Blood Disorders & Transfusion
Open Access

ISSN: 2155-9864

+44 2038689735

Di Zacomo S

  • Review Article
    The Impact of Molecular Genetic in Acute Myeloid Leukemias
    Author(s): Patriarca A, Salutari P and Di Zacomo SPatriarca A, Salutari P and Di Zacomo S

    The discovery and application of advanced molecular techniques, such as gene and microRNA expression profiling, whole genome and exome sequencing and methylation assays, allowed for the identification of recurrent molecular abnormalities in acute myeloid leukemia (AML) that have revolutionized our understanding of the genetic landscape of the disease. Moreover, these modalities have emerged as valuable tools that permit a more comprehensive and detailed molecular characterization of AML, helping in the prediction of prognosis, particularly within the context of cytogenetically normal AML (CN-AML). This review will discuss the major techniques and platforms that have been used to identify novel recurrent gene mutations in AML and briefly describe how these discoveries have impacted on outcome prediction... Read More»
    DOI: 10.4172/2155-9864.1000252

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