David Nathanson
Sweden
Research Article
Exendin-4 Protects Neural Progenitor Cells from Glucolipoapoptosis
Author(s): Shiva Mansouri, Vladimer Darsalia, Mohamed Eweida, Mathias Lundberg, David Nathanson and Cesare PatroneShiva Mansouri, Vladimer Darsalia, Mohamed Eweida, Mathias Lundberg, David Nathanson and Cesare Patrone
Type 2 diabetic and obese patients are under high risk to prematurely develop neurological complications such as stroke and Alzheimer’s disease. Interestingly, type 2-diabetes impairs adult neurogenesis in rodent animal models and this impairment has been suggested to play a role in the brain complications of this disease. Recent work from us and others showed that the treatment with the Glucagon-Like Peptide 1 Receptor (GLP-1R) agonist Exendin-4 stimulates adult neurogenesis in rodents.
Based on these findings we have raised the hypothesis that Exendin-4 may counteract the detrimental effects induced by diabetes in neural stem/progenitor cells. The aim of this study was to investigate whether Exendin-4 protect neural progenitor cells from glucolipotoxicity and to analyse if the regulation of apoptosis may be involved in the Exendin-4 protecting effect. Murine neural p.. View More»
