Journal of Clinical & Experimental Pharmacology

David Johnson

Publications

• Research Article
  Individualised Treatment of Alcohol Dependent Patients with Baclofen: A Clinical Observation
  Author(s): Martin Becker, Lukas Boesch, Markus R Baumgartner, David Johnson and Rudolf StohlerMartin Becker, Lukas Boesch, Markus R Baumgartner, David Johnson and Rudolf Stohler
  
  Abstract Objective: The objective of this observational study was to investigate the effectiveness, safety and tolerability of baclofen in individualised doses for the treatment of alcohol dependence in a sample of patients suffering from additional co-occurring mental disorders. Methods: Fifteen subjects requesting baclofen treatment to achieve abstinence from, or reduction of, alcohol consumption, were included in the study. Baclofen was titrated individually responding to the participants' reports of drug side effects and reductions in drinking and craving. At the start and the end of the observation period (24 weeks) patients self-reported their number of standard drinks per day and rated their alcohol craving by means of the Obsessive Compulsive Drinking Scale (OCD-S). Liver enzymes, Carbohydrate Deficient Transferrin (CDT) and Ethyl Glucuron.. View More»
  DOI: 10.4172/2161-1459.1000163

  Abstract PDF