PMC/PubMed Indexed Articles
Indexed In
- Academic Journals Database
- Genamics JournalSeek
- Academic Keys
- JournalTOCs
- China National Knowledge Infrastructure (CNKI)
- Scimago
- Access to Global Online Research in Agriculture (AGORA)
- Electronic Journals Library
- RefSeek
- Directory of Research Journal Indexing (DRJI)
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- MIAR
- University Grants Commission
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Chuan-Xin Y
Chuan-Xin Y
Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Institute of Parasitic Diseases, Wuxi 214064,
China
Publications
-
Research Article
Synthesis and SAR Studies of New Oxadiazole-2-oxide Derivatives with Remarkable In Vitro Activity against Schistosoma japonicum
Author(s): C M A Gause M, Wen-Hua F, Li-Jun S, Chuan-Xin Y and Bainian FC M A Gause M, Wen-Hua F, Li-Jun S, Chuan-Xin Y and Bainian F
Schistosomiasis is the most neglected tropical disease in the world now where every day more and more people are being affected. The only approved drug Praziquantel (PZQ) that could not prevent re-infection but only effective against adult worms. Resistance of PZQ has been found in some areas, so an alternative drug would be needed as a substitute. Oxadiazole-2-oxide has been proven as potential anti schistosomal agents in which they kill both adult and juvenile worms. We synthesized 25 novel oxadiazole-2-oxide analogues and check their in vitro activity on adult Schistosoma japonicum. In here, all of them showed better in vitro activity than praziquantel and 1, 2, 5-oxadiazole- 2-oxide. Compounds 16, 17, 20, 23 and 24 showed excellent activity even in low concentration and short time period. There are no differences found while checking their in vitro activity against male and female.. View More»
DOI: 10.4172/1948-5948.1000339