Journal of Stem Cell Research & Therapy

Brusse E

Publications

• Review Article
  Ex-vivo Expansion of Muscle-Regenerative Cells for the Treatment of Muscle Disorders
  Author(s): Schaaf G, Sage F, Stok M, Brusse E, Pijnappel WWM, Reuser A and vd Ploeg ATSchaaf G, Sage F, Stok M, Brusse E, Pijnappel WWM, Reuser A and vd Ploeg AT
  
  Skeletal muscle has an impressive regenerative potential. The cells that mediate muscle repair have unique properties that are not restricted solely to the formation of new muscle, but also contribute to the repair of damaged residual tissue. Recent studies have shown that freshly isolated muscle-regenerative cells maintain these properties, and contribute to muscle repair after transplantation to host muscle tissue. Muscle-regenerative cells are typically present in low numbers, and the yield of therapeutic cells from biopsies is low. Ex-vivo expansion of the candidate cells is therefore required. However, when cultured in vitro, the muscle-regenerative cells, and particularly muscle satellite cells, lose their regenerative capacities. This poses a major limitation on the introduction of cell-based therapies for muscle disorders. Here, we take the opportunity to revi.. View More»
  DOI: 10.4172/2157-7633.S11-003

  Abstract PDF