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Bokhan NA
Bokhan NA
Serbia
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Research Article
The Effect of Chronic Alcohol Abuse on the Benzodiazepine Receptor System in Various Areas of the Human Brain
Author(s): Tamara Shushpanova, Bokhan NA, Lebedeva VF, Solonskii AV and Udut VVTamara Shushpanova, Bokhan NA, Lebedeva VF, Solonskii AV and Udut VV
Objective: Alcohol abuse induces neuroadaptive changes in the functioning of neurotransmitter systems in the brain. Decrease of GABAergic neurotransmission found in alcoholics and persons with a high risk of alcohol dependence. Benzodiazepine receptor (BzDR) is allosterical modulatory site on GABA type A receptor complex (GABAAR), that modulate GABAergic function and may be important in mechanisms regulating the excitability of the brain processes involved in the alcohol addiction. The purpose of this study was to investigate the effects of chronic alcohol abuse on the BzDR in various areas of the human brain. Materials and Methods: Investigation of BzDR properties were studied in synaptosomal and mitochondrial membrane fractions from different brain areas of alcohol abused patients and non-alcoholic persons by rad.. View More»
DOI: 10.4172/2378-5756.1000365