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Bo Xi
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Research Article
DNA Methylation in NFATC1 Gene Promoter is Related to Longevity in Chinese Population
Author(s): Chunhong Li, Bo Xi, Tao Zhang, You Li, Jian Wang, Xue Liang, Jian Qin, Wei Chen and Zhiyong ZhangChunhong Li, Bo Xi, Tao Zhang, You Li, Jian Wang, Xue Liang, Jian Qin, Wei Chen and Zhiyong Zhang
Background: NFATC1 gene is associated with age-related complex traits, including longevity, when it overexpresses. DNA methylation in the NFATC1 gene promoter can downregulate the gene expression. This study aims to examine the association between DNA methylation profile in the NFATC1 promoter and family history of longevity in Chinese population. Methods: We recruited 87 individuals in Bama County, Guangxi in China who were grouped into cases with family history of longevity (n=59, mean age=75.6 years) and controls without family history of longevity (n=28, mean age=57.5 years). The DNA methylation profile in the NFATC1 gene promoter was analyzed by pyro sequencing approach. Results: DNA methylation levels were significantly, positively correlated with age at the sites of 77157888, 77157891, and 77157898 and signi.. View More»
DOI: 10.4172/2161-1041.1000179