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Asselineau D
Asselineau D
France
Publications
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Research Article
Aged Human Skin is More Susceptible than Young Skin to Accumulate Advanced Glycoxidation Products Induced by Sun Exposure
Author(s): Pageon H, Poumès-Ballihaut C, Zucchi H, Bastien P, Tancrede E and Asselineau DPageon H, Poumès-Ballihaut C, Zucchi H, Bastien P, Tancrede E and Asselineau D
Background: Skin aging is the result of intrinsic and extrinsic phenomena. Among the factors involved in skin aging, the glycation reaction and the formation of advanced glycation end-products (AGEs) is an important element. AGEs such as carboxy-methyl-lysine (CML) and pentosidine, are formed by an oxidative process, and often referred to as glycoxidation products. AGEs have been reported to accumulate during chronological aging but sun exposure has also been shown to contribute to this accumulation likely through induction of an oxidative environment. The purpose of this study was to investigate the accumulation of AGEs in human skin and, more specifically, CML and pentosidine, both of which are generated by oxidative pathways. Methods: CML and pentosidine immunolabelling were investigated in skin samples from both non photoexposed (sun prote.. View More»
DOI: 10.4172/2329-8847.1000112