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Amy CY Lo
Amy CY Lo
Li Ka Shing Faculty of Medicine,
Hong Kong
China
Publications
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Review Article
Collagen-Based Scaffolds for Cell Therapies in the Injured Brain
Author(s): Francisca SY Wong and Amy CY LoFrancisca SY Wong and Amy CY Lo
Current therapies for treating brain injuries, including stroke and traumatic brain injury, are designed to modify symptoms pharmacologically but do not promote full structural and functional regeneration of the brain. Integrating the merits of cell, biomaterials scaffolds and pharmaceutical therapies, biodegradable scaffold-facilitated cell therapy is a promising multifaceted approach to modify the local injury environment, and also to promote transplanted cell replacement and endogenous regeneration mechanisms. Collagen is an attractive candidate for providing a temporary supportive matrix for cell and drug delivery to the brain. With good biocompatibility, design flexibility and biomimetic properties of the natural extracellular matrix, collagen-based cell transplantation has demonstrated therapeutic potentials in preclinical studies of brain injury. In this review, we will discuss.. View More»
DOI: 10.4172/2157-7633.1000267