Biology and Medicine

Aliaa Monir Higazi

Publications

• Research Article
  Expression Signature of MicroRNA-155 and its Association with Response to Treatment within Different Subtypes of B-Cell Malignancies
  Author(s): Amel Mahmoud Kamal Eldin, Emad Allam Abdel Naem, Aliaa Monir Higazi, Nagwa Ismail Okaily, Mohamed Omar Abdelaziz, Mohamed Shawkat Mohamed, Gehan Lotfy Abdel Hakeem and Marwa Mohamed Abd AllahAmel Mahmoud Kamal Eldin, Emad Allam Abdel Naem, Aliaa Monir Higazi, Nagwa Ismail Okaily, Mohamed Omar Abdelaziz, Mohamed Shawkat Mohamed, Gehan Lotfy Abdel Hakeem and Marwa Mohamed Abd Allah
  
  Objectives: Emerging evidence suggests that microRNAs could serve as non-invasive biomarkers for cancer patients. However, they are mostly not fully investigated as biomarkers in the classification, progression and prognosis of different cancers. Our study was designed to explore the microRNA-155 (miR-155) expression levels in peripheral blood mononuclear cells (PBMCs) in patients with various subtypes of B-cell malignancies. Also, we aimed to correlate between miR-155 expression levels and the diverse clinico-pathologic features as well as the prognostic fate of these patients after treatment completion. Subjects and methods: Using whole blood samples from 53 patients with B-cell malignancies and 15 apparently healthy subjects, miR-155 was extracted and profiled by quantitative real-time PCR (RT-qPCR). The B-cell malignancies patients were including 22 diffuse large B-cell lymphoma (.. View More»
  DOI: 10.4172/0974-8369.1000375

  Abstract PDF